HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid → (cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridin-1-yl)-(1-methyl-1H-benzotriazol-5-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid | HCID 2776549 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine | HCID 58123900 | — |
| Product | (cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridin-1-yl)-(1-methyl-1H-benzotriazol-5-yl)-methanone | HCID 67224220 | 65% |
Reaction Steps
The title compound is prepared from 1-methyl-1H-benzotriazole-5-carboxylic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexa-fluorophosphate is used]. Yield: 65% of theory; LC (method 4): tR=1.88 min; Mass spectrum (ESI+): m/z=333 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497281B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-190c79b94fcc4b7393ab59388f6f0787 |
| Source note | uspto-grants-2013_07 |