化工社化工社 化学情報印刷レポート · 研究参考用
1,3-Dibromopropane → Didesmethylsibutramine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dibromopropane | HCID 8001 | — |
| 反応物 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 生成物 | Didesmethylsibutramine | HCID 134772 | 56.2% |
反応手順
As described in article (Chinese Journal of Pharmaceuticals, 2001, 32(8): 337-339), p-chlorobenzyl cyanide was condensed with 1,3-dibromopropane, cycled to give cyclobutyl intermediate, and then through Grignard reaction and reduction reaction to give title compound (56.2% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497305B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-f61af2fe89974ddbb36cdcc704faf1e5 |
| 出典メモ | uspto-grants-2013_07 |