HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Didesmethylsibutramine → Didesmethylsibutramine, (+)-
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Didesmethylsibutramine | HCID 134772 | — |
| Edukt | D-Tartaric acid | HCID 439655 | — |
| Produkt | Didesmethylsibutramine, (+)- | HCID 9900576 | — |
Reaktionsschritte
As described above, D-(−)-tartaric acid was used to resolute racemic compound II to give another optical isomer (75.2% yield). This optical isomer were treated with alkaline to give free base (R)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine (II-R) (optical purity 99.4%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08497305B2 |
| Quelldatensatz | uspto-grants-2013_07 |
| ORD ID | ord-069e4819db2847d492317edf0ab902d5 |
| Quellennotiz | uspto-grants-2013_07 |