反应详情

温度

90 °C

In a 250-mL flask, Lawesson's reagent (0.577 g, 1.427 mmol) and (S)-2′-bromo-4′-fluoro-7′-methoxyspiro[morpholine-3,9′-xanthen]-5-one (0.978 g, 2.481 mmol) were suspended in toluene (25 mL). An air-cooled condenser was attached, and the flask was heated in a 90° C. oil bath for 3 h. The mixture was then cooled and concentrated to give (S)-2′-bromo-4′-fluoro-7′-methoxyspiro[morpholine-3,9′-xanthene]-5-thione which was used in the next step without further purification.

1. customAn air-cooled condenser was attached
2. temperatureThe mixture was then cooled
3. concentrationconcentrated