反应详情

温度

90 °C

In a 1-L flask, the (S)-2′-bromo-4′-fluoro-7′-methoxyspiro[morpholine-3,9′-xanthen]-5-one (3.16 g, 8.02 mmol) was suspended in toluene (75 mL). Lawesson's reagent (1.864 g, 4.61 mmol) was added. An air-cooled condenser was affixed, and the mixture was heated in a 90° C. oil bath for 2 h. The mixture was cooled and concentrated to afford crude (S)-2′-bromo-4′-fluoro-7′-methoxyspiro[morpholine-3,9′-xanthene]-5-thione which was used in the next step without further purification.

1. customAn air-cooled condenser was affixed
2. temperatureThe mixture was cooled
3. concentrationconcentrated