反应详情

Next, 3.87 g of 2-chloro-3-(4-fluorophenyl)pyrazine, 2.01 g of sodium methoxide, and 30 mL of methanol were put in a three-neck flask equipped with a reflux pipe, and reacted by being heated and refluxed under a nitrogen atmosphere for three hours. After the reaction, the reaction solution was cooled down to room temperature, water was added thereto, and an organic layer was extracted with dichloromethane. The obtained organic layer was washed with a saturated saline and water, and dried with magnesium sulfate. Then, magnesium sulfate was removed by filtration and the solvent was distilled off, so that 2-(4-fluorophenyl)-3-methoxypyrazine was obtained (milky white powder, yield: 96%). A synthetic scheme of Step 2 is shown in the following (a1-2).

1. customequipped with a reflux pipe
2. customreacted
3. temperatureby being heated
4. temperaturerefluxed under a nitrogen atmosphere for three hours
5. customAfter the reaction
6. extractionan organic layer was extracted with dichloromethane
7. washThe obtained organic layer was washed with a saturated saline and water
8. dry with materialdried with magnesium sulfate
9. customThen, magnesium sulfate was removed by filtration
10. distillationthe solvent was distilled off, so that 2-(4-fluorophenyl)-3-methoxypyrazine
11. customwas obtained (milky white powder, yield: 96%)