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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 45568Generated: October 25, 2026

4-Toluenesulfonyl chloride → 2,2-Difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate

https://huagongshe.com/reaction/45568

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
Reactant2,2-Difluoro-2-(pyridin-2-YL)ethanolHCID 9942216—
Product2,2-Difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonateHCID 58249642—

Reaction Steps

reacting 2,2-difluoro-2-pyridin-2-ylethanol with 4-toluenesulfonyl chloride to form 2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate, which is converted to compound of formula (K2); and

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08541580B2
Source datasetuspto-grants-2013_09
ORD IDord-1f8c84fff2814dc9b905798423f88e43
Source noteuspto-grants-2013_09