2-Fluoropyridine-3-boronic acid → (S)-1-fluoro-7-(2-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoropyridine-3-boronic acid	HCID 2783270	—
Reactant	2-Fluoropyridine-4-boronic acid	HCID 2783396	—
Reactant	(S)-7-bromo-3-chloro-1-fluoro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465925	—
Product	(S)-1-fluoro-7-(2-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465987	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A1 above, but using intermediate 15B, 2-fluoropyridin-3-ylboronic acid and 2-fluoropyridin-4-ylboronic acid. MS m/z=476.0 [M+H]+. Calculated for C25H16F3N5O3: 475.13

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497264B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-6552043894144abbb9ae8d0c34b0c35c
Source note	uspto-grants-2013_07