2-Fluoropyridine-4-boronic acid → (S)-1-fluoro-7-(5-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoropyridine-4-boronic acid	HCID 2783396	—
Reactant	(5-Fluoropyridin-3-yl)boronic acid	HCID 44717403	—
Reactant	(S)-7-bromo-3-chloro-1-fluoro-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465925	—
Product	(S)-1-fluoro-7-(5-fluoropyridin-3-yl)-3-(2-fluoropyridin-4-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazin]-2'-amine	HCID 58465967	—

Reaction Steps

The title compound was synthesized by steps analogous to those described in method A1 above, but using intermediate 15B, 5-fluoropyridin-3-ylboronic acid and 2-fluoropyridine-4-boronic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497264B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-5f67d3a31fa84d0495307b376ed1c78a
Source note	uspto-grants-2013_07