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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 455746Generated: October 30, 2026

3,3-Difluoropyrrolidine hydrochloride → HCID 58465941, compound

https://huagongshe.com/reaction/455746

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-Difluoropyrrolidine hydrochlorideHCID 24903482—
Reactant(5-Fluoropyridin-3-yl)boronic acidHCID 44717403—
Reactant(S)-7-bromo-3-chloro-2',6'-dihydrospiro[chromeno [2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amineHCID 58465879—
ProductHCID 58465941HCID 58465941—

Reaction Steps

The title compound was synthesized by steps analogous to those described in Method A3, but using Intermediate 10B, 5-fluoropyridin-3-ylboronic acid, and 3,3-difluoropyrrolidine hydrochloride. MS m/z=468.3 [M+H]+. Calculated for C24H20FN5O2: 467.16.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497264B2
Source datasetuspto-grants-2013_07
ORD IDord-5726c19b149c452a96e679e4f3b91295
Source noteuspto-grants-2013_07