Diisopropylethylamine → HCID 52945681, compound

Participants

Reaction Steps

To a solution of pyridine dithioethylamine hydrochloric salt (15.8 mg, 0.071 mmole) in anhydrous DMF (1.5 mL) was added DIEA (25 μL, 0.142 mmole) followed by a solution of tubulysin A (40 mg, 0.047 mmole) in anhydrous DMF (0.5 mL). The reaction mixture was stirred under argon at room temperature for 2 h. The mixture was then evaporated under vacuum. The crude product was purified by silica gel column chromatography (CH2Cl2/MeOH, 15/1) to afford white solid (54 mg) in quantitative yield.

Provenance & Evidence