HCID 136391012, compound → Udenafil

HRID 455917Notes

Reaction equation

HRID 455917 reaction equation
[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([S:25]([NH:28][CH2:29][CH2:30][CH:31]4[N:35]([CH3:36])[CH2:34][CH2:33][CH2:32]4)(=[O:27])=[O:26])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH2:23][CH3:24])[NH:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1.Cl>C(O)C>[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([S:25]([NH:28][CH2:29][CH2:30][CH:31]4[N:35]([CH3:36])[CH2:34][CH2:33][CH2:32]4)(=[O:27])=[O:26])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH2:23][CH3:24])[NH:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1

Participants

3

Reactant 1

HCID 136391012HCID 136391012, compound2×

Product 1

HCID 135413547UdenafilYield 170.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

20 g of sodium CMC is dissolved in water to form a 5% viscous aqueous solution (40 ml). Udenafil HCl (20.6 g) is added to the solution and the mixture is stirred at 50° C. for 1 hr to obtain a white precipitate. The solution is poured out then the ethanol (100 ml) is added for dehydration. Ethanol (100 ml) is added additionally to wash out the unreacted Udenafil, over night and warmed in water bath at 50° C. and cooled at room temperature over night to obtain the precipitate of Udenail-CMC complex (32.8 g).

Workup

  1. customto obtain a white precipitate
  2. additionThe solution is poured out
  3. washto wash out the unreacted Udenafil, over night
  4. temperaturewarmed in water bath at 50° C.
  5. temperaturecooled at room temperature over night

Sources & evidence

ORD record
ord-824199611a414c13a137014c68284456
Source dataset
uspto-grants-2013_07
Patent number
US08497370B2

Reaction notes

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