Lithium Hydroxide → 5-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Lithium Hydroxide	HCID 3939	—
Reactant	Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate	HCID 56604575	—
Solvent	Methanol	HCID 887	—
Solvent	Water	HCID 962	—
Product	5-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid	HCID 56604559	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (39 mmol) in MeOH (50 mL) and H2O (10 mL) was treated with lithium hydroxide (2 g, 48 mmol), and the reaction was stirred at 60° C. for 1 hour. The mixture was acidified, and standard workup provided the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541587B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-947f4b35867c4b6eb29ad3aa405d9e6a
Source note	uspto-grants-2013_09