反应详情

Pipemidic acid (54 mg, 0.177 mmol) and m-tolylisothiocyanate (20 μL, 0.148 mmol) were used. Purification on silica yielded compound 13 in Table 1, below (67 mg, 100%). 1H NMR (300 MHz, CDCl3) δ 9.32 (s, 1H), 8.68 (s, 1H), 7.34-7.32 (m, 1H), 7.05-6.94 (m, 3H), 4.33 (q, J=7.10 Hz, 2H), 4.24-3.87 (m, 8H), 2.35 (s, 3H), 1.49 (t, J=7.19 Hz, 3H) ppm.

1. customPurification on silica yielded compound 13 in Table 1