反应详情

Pipemidic acid (25 mg, 0.0824 mmol) and 2-fluorophenyl isothiocyanate (10 μL, 0.0824 mmol) were used. Purification on silica yielded compound 30 in Table 1, below (24 mg, 64%). 1H NMR (300 MHz, CDCl3) δ 9.35 (s, 1H), 8.69 (s, 1H), 7.64 (t, J=7.34 Hz, 1H), 7.21-7.12 (m, 3H), 4.35 (q, J=6.90 Hz, 2H), 4.28-4.02 (m, 8H), 1.50 (t, J=7.09 Hz, 3H) ppm.

1. customPurification on silica yielded compound 30 in Table 1