HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-{1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl}-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {5-[4'-(1-Methanesulfonylaminocarbonyl-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-yl}-carbamic acid tert-butyl ester | HCID 66577855 | — |
| Reactant | Sodium bicarbonate ethyl acetate | HCID 86584982 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarbonyl}-methanesulfonamide | HCID 66577832 | — |
Reaction Steps
{5-[4′-(1-Methanesulfonylaminocarbonyl-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-yl}-carbamic acid tert-butyl ester (0.25 g, 0.49 mmol)) in CH2Cl2 (2 mL) and TFA (2 mL) was stirred overnight then poured into EtOAc/NaHCO3 (aq). The organic layer was concentrated to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541587B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-a715fe4c2359439cae7db5105e23cd95 |
| Source note | uspto-grants-2013_09 |