反应详情

By an operation similar to that in Example 2-1 and using 2-{[4-(chloroacetyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (1.49 g) obtained in Example 1 and 4′-chlorobiphenyl-4-ol (772 mg), 2-[(4-{[(4′-chlorobiphenyl-4-yl)oxy]acetyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (864 mg) was obtained. By successive operations similar to those in Example 2-2 and 2-3 using 568 mg thereof, the title compound (299 mg) was obtained.