Phenyltrimethylammonium bromide dibromide → HCID 58451404, compound

Participants

Reaction Steps

2-{[4-Acetyl-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (15.90 g) obtained in Example 8 was dissolved in tetrahydrofuran (150 mL), phenyltrimethylammonium tribromide (21.81 g) was added by small portions over 15 min, and the mixture was stirred at room temperature overnight. The precipitated solid was filtered off, the solvent was evaporated, and the residue was dissolved in ethyl acetate (200 mL). The solution was washed successively with water and saturated aqueous sodium chloride solution (each 100 mL) and dried over anhydrous sodium sulfate. The solvent was evaporated and the obtained residue was purified by column chromatography (Yamazen HI-FLASH™ COLUMN size 3 L, elution solvent: hexane/ethyl acetate-90/10-50/50, performed in 5 times) to give the title compound (12.28 g).

Provenance & Evidence