Methanesulfonohydrazide → HCID 71699877, compound

HRID 456076Notes

Reaction equation

HRID 456076 reaction equation
[CH3:1][S:2]([NH:5][NH2:6])(=[O:4])=[O:3].[F:7][C:8]1[CH:17]=[C:16]2[C:11]([CH:12]=[CH:13][CH:14]=[N:15]2)=[CH:10][C:9]=1[CH2:18][C:19]1[N:23]2[N:24]=[C:25]([C:28](=O)[CH3:29])[CH:26]=[CH:27][C:22]2=[N:21][CH:20]=1>>[F:7][C:8]1[CH:17]=[C:16]2[C:11]([CH:12]=[CH:13][CH:14]=[N:15]2)=[CH:10][C:9]=1[CH2:18][C:19]1[N:23]2[N:24]=[C:25](/[C:28](=[N:6]/[NH:5][S:2]([CH3:1])(=[O:4])=[O:3])/[CH3:29])[CH:26]=[CH:27][C:22]2=[N:21][CH:20]=1

Participants

3

Reactant 2

HCID 269268MethanesulfonohydrazideHCID 581905991-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]ethanone

Product 1

HCID 71699877HCID 71699877, compoundYield 60%

Procedure

The title compound was prepared from methanesulfonohydrazide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 60% yield. 1H-NMR (400 MHz, DMSO-d6) δ ppm 10.63 (s, 1H), 8.85 (dd, 1H), 8.30 (d, 1H), 8.09 (d, 1H), 7.94 (d, 1H), 7.75 (m, 3H), 7.47 (q, 1H), 4.58 (s, 2H), 3.10 (s, 3H), 2.26 (s, 3H). LCMS (method A): [MH]+=413, tR=4.57 min.

Sources & evidence

ORD record
ord-d5339f17d5b145c89042e3943feaca89
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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