4-Ethyl-3-thiosemicarbazide → HCID 71699878, Verbindung
Reaktionsgleichung
[CH2:1]([NH:3][C:4]([NH:6][NH2:7])=[S:5])[CH3:2].[F:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[CH2:19][C:20]1[N:24]2[N:25]=[C:26]([C:29](=O)[CH3:30])[CH:27]=[CH:28][C:23]2=[N:22][CH:21]=1>>[CH2:1]([NH:3][C:4]([NH:6]/[N:7]=[C:29](/[C:26]1[CH:27]=[CH:28][C:23]2[N:24]([C:20]([CH2:19][C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][C:9]=3[F:8])[N:16]=[CH:15][CH:14]=[CH:13]4)=[CH:21][N:22]=2)[N:25]=1)\[CH3:30])=[S:5])[CH3:2]Komponenten
3
Versuchsvorschrift
The title compound was prepared from N-ethylhydrazine carbothioamide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 53% yield. 1H-NMR (400 MHz, MeOH-d4) δ ppm 8.83 (d, 1H), 8.30 (d, 1H), 8.24 (d, 1H), 7.93 (m, 2H), 7.69 (m, 2H), 7.48 (q, 1H), 4.67 (s, 2H), 3.74 (q, 2H), 2.39 (s, 3H), 1.26 (t, 3H). LCMS (method A): [MH]+=422, tR=5.43 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-289f813fac0440ff8e8f8c8c1c67d4e1
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08497368B2
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