6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(4,6-difluoro-1-methyl-1H-indazol-5-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde	HCID 11446702	—
Reactant	4,6-Difluoro-1-methyl-1H-indazole	HCID 57917479	—
Reactant	1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethanol	HCID 58147529	—
Product	(6-Chloroimidazo[1,2-b]pyridazin-3-yl)(4,6-difluoro-1-methyl-1H-indazol-5-yl)methanol	HCID 58190595	41%

Reaction Steps

The title compound as a yellow solid (60 mg, 0.172 mmol, 41%) was synthesized from intermediate 4,6-Difluoro-1-methyl-1H-indazole (70 mg, 0.416 mmol) and 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde (76 mg, 0.416 mmol) using the same procedure as described in the synthesis of compound 31.1. 1H-NMR (400 MHz, MeOH-d4) δ ppm 8.08 (s, 1H), 8.03 (d, 1H), 7.85 (s, 1H), 7.26 (q, 2H), 6.76 (s, 1H), 4.03 (s, 3H). LCMS (method B): [MH]+=349.9, tR=2.12 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497368B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-85a7151f47e64ec38ca80a96227e8fc6
Source note	uspto-grants-2013_07