反应详情

温度

45 °C

1-(3-(difluoro(quinolin-6-yl)methyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone (25 mg, 0.074 mmol) and 2-morpholinoacetohydrazide (12 mg, 0.075 mmol) were dissolved in MeOH and the pH of the reaction solution was adjusted to 5. The solution was then stirred at 45° C. for 3 hours. Solvent was evaporated and the crude product was purified on HPLC (neutralized to free base) to give the title compound as a white solid (18 mg, 50%). 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.02 (s, 1H), 8.55 (d, 1H), 8.43 (d, 2H), 8.17 (d, 1H), 8.01 (m, 2H), 7.65 (d, 1H), 3.59 (m, 4H), 2.13 (m, 4H). LCMS (method B): [MH]+=481.1, tR=1.66 min.

1. customSolvent was evaporated
2. customthe crude product was purified on HPLC (neutralized to free base)