HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 1-(Quinolin-6-yl)cyclopropanecarbohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 1-(quinolin-6-yl)cyclopropanecarboxylate | HCID 58190477 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Quinolin-6-yl)cyclopropanecarbohydrazide | HCID 66927158 | 100% |
Reaction Steps
A solution of 1-quinolin-6-yl-cyclopropanecarboxylic acid methyl ester (513 mg, 2.26 mmol) and hydrazine monohydrate (3.39 g, 67.7 mmol) in methanol (5 mL) was heated under reflux overnight. After cooling, the solvent was removed in vacuo to afford 513 mg (100%) of the title compound and used without further purification. LCMS (method A): [MH]+=228, tR=2.88 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497368B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-a43a402029b649049326699f8de4c99d |
| Source note | uspto-grants-2013_07 |