2-(4-Morpholinyl)acetohydrazide → HCID 71699910, compound

HRID 456126Notes

Reaction equation

HRID 456126 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][N:12]3[C:16]4=[N:17][C:18]([C:21](=O)[CH3:22])=[CH:19][N:20]=[C:15]4[N:14]=[N:13]3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][C:31]([NH:33][NH2:34])=[O:32])[CH2:26][CH2:25]1>>[O:24]1[CH2:25][CH2:26][N:27]([CH2:30][C:31]([NH:33]/[N:34]=[C:21](/[C:18]2[N:17]=[C:16]3[N:12]([CH2:11][C:7]4[CH:6]=[C:5]5[C:10](=[CH:9][CH:8]=4)[N:1]=[CH:2][CH:3]=[CH:4]5)[N:13]=[N:14][C:15]3=[N:20][CH:19]=2)\[CH3:22])=[O:32])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 3516352-(4-Morpholinyl)acetohydrazideHCID 593418021-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone

Product 1

HCID 71699910HCID 71699910, compound

Procedure

The title compound was prepared in analogy to the synthesis of example 52 from 1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone and 2-morpholinoaceto-hydrazide. The title compound was obtained as light yellow solid. 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.45 (d, 1H), 8.90 (d, 1H), 8.36 (d, 1H), 8.01 (m, 2H), 7.83 (d, 1H), 7.53 (dd, 1H), 6.20 (s, 2H), 3.65 (d, 4H), 3.26 (s, 2H), 2.57 (d, 4H), 2.41 (s, 3H). LCMS (method B): [MH]+=446.2, tR=1.37 min.

Sources & evidence

ORD record
ord-c33e89b51c774a209623ec5889d2681f
Source dataset
uspto-grants-2013_07
Patent number
US08497368B2

Reaction notes

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