6-[6-(1-Ethoxy-vinyl)[1,2,3]triazolo[4,5-b]pyrazin-1-ylmethyl]-quinoline → 6-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

Participants

Reaction Steps

The title compound was prepared in analogy to the synthesis of compound 52.3 from 6-(1-(6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.17 (9.17 (s, 1H), 8.90 (m, 1H), 8.10 (d, 1H), 7.89 (d, 1H), 7.78 (d, 1H), 7.39 (dd, 1H), 6.82 (q, 1H), 5.56 (d, 1H), 4.56 (d, 1H), 4.04 (q, 2H), 2.30 (d, 3H), 1.48 (t, 3H). LCMS (method B): [MH]+=365, tR=2.55 min.

Provenance & Evidence