1-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone → 1-(1-(1-(7-Fluoroquinolin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone
Reaktionsgleichung
N1C2C(=CC(CN3C4=NC(C(=O)C)=CN=C4N=N3)=CC=2)C=CC=1.C([O:26][C:27]([C:29]1[N:34]=[C:33]2[N:35]([CH:38]([C:40]3[CH:41]=[C:42]4[C:47](=[CH:48][C:49]=3[F:50])[N:46]=[CH:45][CH:44]=[CH:43]4)[CH3:39])[N:36]=[N:37][C:32]2=[N:31][CH:30]=1)=[CH2:28])C>>[F:50][C:49]1[CH:48]=[C:47]2[C:42]([CH:43]=[CH:44][CH:45]=[N:46]2)=[CH:41][C:40]=1[CH:38]([N:35]1[C:33]2=[N:34][C:29]([C:27](=[O:26])[CH3:28])=[CH:30][N:31]=[C:32]2[N:37]=[N:36]1)[CH3:39]Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to the synthesis of compound of 52.4 from 6-(1-(6-(1-ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.44 (s, 1H), 8.93 (m, 1H), 8.13 (d, 1H), 7.94 (s, 1H) 7.79 (d, 1H), 7.41 (dd, 1H), 6.88 (q, 1H), 2.76 (s, 3H), 2.37 (d, 3H). LCMS (method B): [MH]+=337, tR=2.21 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-af339235733e40798c032325a933c498
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08497368B2
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