6-(1-Ethoxyvinyl)-3-(1-(6-fluoro-1-methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazine → 6-(1-Ethoxyvinyl)-3-((6-fluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([C:12]([CH:15]([C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][C:25]=3[F:26])[N:22]([CH3:27])[N:21]=[CH:20]4)C)=[CH:13][N:14]=2)[N:11]=1)=[CH2:5])[CH3:2].ClC1C=CC2N(C(CC3C=C4C(=CC=3F)N(C)N=C4)=CN=2)N=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([C:12]([CH2:15][C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][C:25]=3[F:26])[N:22]([CH3:27])[N:21]=[CH:20]4)=[CH:13][N:14]=2)[N:11]=1)=[CH2:5])[CH3:2]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared in analogy to the synthesis of compound 68.3 from 6-chloro-3-((6-fluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine.
Sources & evidence
- ORD record
- ord-cd24b2eb9d7b46e59bdaea8d48e332b0
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08497368B2
Reaction notes
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