Semicarbazide → [(E)-1-[3-[1-(1-methylindazol-5-yl)ethyl]imidazo[1,2-b]pyridazin-6-yl]ethylideneamino]urea

Participants

Reaction Steps

The title compound (14.0 mg, 59%) was synthesized from 1-(3-(1-(1-methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazin-6-yl)ethanone (20.0 mg, 0.06 mmol) and hydrazinecarboxamide (13.97 mg, 0.13 mmol) using the same procedure as described in the synthesis of example 69. 1H-NMR (400 MHz, CDCl3) δ ppm 8.33 (s, 1H), 7.87 (m, 2H), 7.66 (m, 3H), 7.32 (m, 2H), 4.74 (q, 1H), 4.03 (s, 3H), 2.24 (s, 3H), 1.84 (d, 3H). LCMS (method A): [MH]+=377, tR=4.70 min.

Provenance & Evidence