Semicarbazide hydrochloride → HCID 50898365, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[3-(7-fluoro-quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl]-ethanone (30.0 mg, 0.09 mmol) in MeOH (10 mL), was added hydrazinecarboxamide hydrochloride (31.0 mg, 0.28 mmol). The mixture was heated at 45° C. and stirred overnight. The solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography with gradient (DCM:MeOH=10:1) to give the title compound as a white solid (25.0 mg, 67%). 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.91 (s, 1H), 9.85 (s, 1H), 8.93 (dd, 1H), 8.42 (d, 1H), 8.185 (d, 1H), 7.83 (d, 1H), 7.54 (dd, 1H), 6.20 (s, 2H), 2.28 (s, 3H). LCMS (method A): [MH]+=380, tR=1.98 min.

Provenance & Evidence