Isoniazid → HCID 50915994, compound

Participants

Reaction Steps

The title compound (27.9 mg, 64%) was synthesized from 1-[3-(7-fluoro-quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl]-ethanone (30.0 mg, 0.09 mmol) and isonicotinic acid hydrazide (38.3 mg, 0.28 mmol) using the same procedure as described in the synthesis of example 72. 1H-NMR (400 MHz, DMSO-d6) δ ppm 11.75, 11.39 (bs, 1H), 9.51 (s, 1H), 8.93 (dd, 1H), 8.79 (m, 2H), 8.42 (d, 1H), 8.20 (d, 1H), 7.836 (m, 3H), 7.54 (dd, 1H), 6.25 (s, 2H), 2.49 (s, 3H). LCMS (method E): [MH]+=442, tR=4.59 min.

Provenance & Evidence