反应详情

To [6-methoxy-2′-(2-oxo-oxazolidin-3-ylmethyl)-4′-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester (0.117 g, 0.28 mmol) in THF (1.2 mL) and MeOH (0.9 mL) was added 1N aqueous NaOH (0.61 mL), and the reaction was stirred at room temperature for 1 hour. Once no starting material was seen by analytical LCMS, the mixture was diluted with CH2Cl2 and aqueous HCl. The aqueous layer was separated and extracted with CH2Cl2, and the combined organic layers were dried over MgSO4, filtered, and concentrated. The crude material was purified by silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound. M+H is 410.

1. customThe aqueous layer was separated
2. extractionextracted with CH2Cl2
3. dry with materialthe combined organic layers were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude material was purified by silica gel chromatography (0-100% EtOAc in hexanes)