Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate → HCID 58120004, compound

HRID 456202Notes

Reaction equation

HRID 456202 reaction equation
Br[C:2]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:3]=1[CH2:4][N:5]1[C@@H:9]([CH3:10])[C@@H:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:7][C:6]1=[O:17].[CH3:24][O:25][C:26](=[O:45])[CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30](B2OC(C)(C)C(C)(C)O2)[CH:29]=1>>[CH3:24][O:25][C:26](=[O:45])[CH2:27][C:28]1[CH:29]=[C:30]([C:2]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:3]=2[CH2:4][N:5]2[C@@H:9]([CH3:10])[C@@H:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:17])[C:31]([O:34][CH3:35])=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 57576289Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 58120069HCID 58120069, compound

Product 1

HCID 58120004HCID 58120004, compound

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (4S,5R)-3-(2-bromo-5-methoxy-benzyl)-4-methyl-5-phenyl-oxazolidin-2-one and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3b17d81700e84ce5a144a115644e51a7
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Reaction notes

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