3-Bromo-4-fluorophenylacetic Acid → HCID 44205723, compound

HRID 456208Notes

Reaction equation

HRID 456208 reaction equation
[CH3:1][C@H:2]1[C@@H:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][C:4](=[O:13])[N:3]1[CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1B1OC(C)(C)C(C)(C)O1.Br[C:35]1[CH:36]=[C:37]([CH2:42][C:43]([OH:45])=[O:44])[CH:38]=[CH:39][C:40]=1[F:41]>>[F:41][C:40]1[C:35]([C:16]2[CH:17]=[CH:18][C:19]([C:21]([F:23])([F:22])[F:24])=[CH:20][C:15]=2[CH2:14][N:3]2[C@@H:2]([CH3:1])[C@@H:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[O:5][C:4]2=[O:13])=[CH:36][C:37]([CH2:42][C:43]([OH:45])=[O:44])=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 34163393-Bromo-4-fluorophenylacetic AcidHCID 66890959(4S,5R)-4-Methyl-5-phenyl-3-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-oxazolidin-2-one

Product 1

HCID 44205723HCID 44205723, compound

Procedure

Prepared according to the procedure described in Example 7, Step 2, using the following starting materials: (4S,5R)-4-methyl-5-phenyl-3-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-oxazolidin-2-one and 3-bromo-4-fluorophenylacetic acid. M+H is 488.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e5f064f314d741cdbcf487a01ac94a2b
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Reaction notes

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