(1R,2S)-(+)-cis-1-Amino-2-indanol → HCID 66608540, compound

Participants

Reaction Steps

(2′-Formyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester (0.153 g, 0.43 mmol), (1R,2S)-(+)-cis-1-amino-2-indanol (0.065 g, 0.43 mmol), sodium cyanoborohydride (0.041 g, 0.65 mmol), and acetic acid (3 drops) were combined in CH2Cl2 (1.5 mL), and the reaction was stirred for 30 minutes at room temperature. The mixture was diluted with CH2Cl2 and saturated aqueous NaHCO3, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated to give the title compound.

Provenance & Evidence