Phosgene → HCID 66891582, compound

Participants

Reaction Conditions

Reaction Steps

To {2′-[((1R,2S)-2-hydroxy-indan-1-ylamino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester (0.178 g, 0.37 mmol) in toluene (3 mL) was added triethylamine (0.18 mL, 1.29 mmol), and the mixture was cooled to 0° C. Phosgene (1.9M in toluene; 0.23 mL, 0.44 mmol) was added, and the reaction was stirred for 20 minutes at 0° C. The mixture was diluted with EtOAc, H2O, and brine, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound.

Provenance & Evidence