Phosgene → HCID 66891061, compound

HRID 456240Notes

Reaction equation

HRID 456240 reaction equation
[CH3:1][O:2][C:3](=[O:35])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH2:23][NH:24][C@H:25]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:27][C@H:26]2[OH:34])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.[C:36](Cl)(Cl)=[O:37]>>[CH3:1][O:2][C:3](=[O:35])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:20])[F:21])=[CH:15][C:14]=2[CH2:23][N:24]2[C@H:25]3[C:33]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH2:27][CH:26]3[O:34][C:36]2=[O:37])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 66890000HCID 66890000, compound

Product 1

HCID 66891061HCID 66891061, compound

Procedure

Prepared according to the procedure described in Example 25, Step 5, using the following starting materials: {2′-[((1S,2R)-2-hydroxy-indan-1-ylamino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester and phosgene (1.9M in toluene).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c63f393f08ba4555a058a7278640e369
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Reaction notes

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