HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,2R)-(-)-1-Amino-2-indanol → {6-fluoro-2'-[((1S,2R)-2-hydroxy-indan-1-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| Reactant | (6-Fluoro-2'-formyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester | HCID 86633169 | — |
| Product | {6-fluoro-2'-[((1S,2R)-2-hydroxy-indan-1-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester | HCID 66890168 | — |
Reaction Steps
Prepared according to the procedure described in Example 25, Step 4, using the following starting materials: (6-fluoro-2′-formyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester and (1S,2R)-(−)-cis-1-amino-2-indanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497381B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-a2e5f883c32e439dabe1b013f8ddb598 |
| Source note | uspto-grants-2013_07 |