HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → [6-Fluoro-2'-((3aS,8aR)-2-oxo-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | {6-fluoro-2'-[((1S,2R)-2-hydroxy-indan-1-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester | HCID 66890168 | — |
| Product | [6-Fluoro-2'-((3aS,8aR)-2-oxo-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester | HCID 66892267 | — |
Reaction Steps
Prepared according to the procedure described in Example 25, Step 5, using the following starting materials: {6-fluoro-2′-[((1S,2R)-2-hydroxy-indan-1-ylamino)-methyl]-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester and phosgene (1.9M in toluene).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497381B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-bb821c67e1be4d2b9b1eda8081e4caa0 |
| Source note | uspto-grants-2013_07 |