(1R,2S)-(+)-cis-1-Amino-2-indanol → {6-fluoro-2'-[((1R,2S)-2-hydroxy-indan-1-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 456244Notes

Reaction equation

HRID 456244 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[C:8]([F:11])=[CH:9][CH:10]=1.[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C@@H:27]([NH2:34])[C@H:26]1[OH:35]>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:14][C:13]=2[CH2:22][NH:34][C@@H:27]2[C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:25][C@@H:26]2[OH:35])[C:8]([F:11])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 86633169(6-Fluoro-2'-formyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 66891555{6-fluoro-2'-[((1R,2S)-2-hydroxy-indan-1-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 25, Step 4, using the following starting materials: (6-fluoro-2′-formyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester and (1R,2S)-(+)-cis-1-amino-2-indanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-de9634cf6fab41b482d9aa460caed0d8
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Reaction notes

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