Phosgene → HCID 66891042, compound

HRID 456247Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH2:23][NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.[C:33](Cl)(Cl)=[O:34]>>[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH2:23][N:24]2[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][C:33]2=[O:34])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

Participants

Reactant 2

HCID 6371Phosgene

HCID 66891384HCID 66891384, compound

Product 1

HCID 66891042HCID 66891042, compound

Procedure

Prepared according to the procedure described in Example 25, Step 5, using the following starting materials: {2′-[(2-hydroxy-phenylamino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester and phosgene (1.9M in toluene).

Workup

customPrepared

Sources & evidence

ORD record: ord-59b0b5d6ff1141cf818032d65255b85d
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08497381B2

Reaction notes

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