4-Nitrobenzenesulfonyl chloride → HCID 70201301, compound

Participants

Reaction Steps

To a solution of tert-butyl (3R,4R)-4-amino-1-benzylpyrrolidin-3-ylcarbamate (5.8 g, 20 mmol) in 100 mL of CH2Cl2, triethylamine (4.04 g, 40 mmol) was added following by addition of 4-nitrobenzenesulfonyl chloride (1.1 eq) and the mixture was stirred at room temperature overnight. The reaction was quenched with saturated aqueous NH4Cl, extracted with CH2Cl2, the combined organic extracts were dried with Na2SO4 and evaporated. The residue was purified by column chromatography on silica gel eluting with 1-2% MeOH in CHCl3 to give the title product.

Provenance & Evidence