1-Chloroethyl chloroformate → HCID 68019354, compound

Participants

Reaction Steps

A mixture of N-(2-{[(3R,4R)-1-benzyl-4-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}pyrrolidin-3-yl](methyl)amino}ethyl)-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide (168 mg, 0.15 mmol), 1-chloroethyl chloroformate (72 mg, 0.5 mmol) in 1.5 mL of 1,2-dichloroethane was stirred overnight at reflux. The solvent was evaporated, the residue was re-dissolved in MeOH and the mixture was refluxed for 1 hour. MeOH was evaporated and the residue containing compound the deprotected pyrrolidine was used for the next step without additional purification. LC-MS APCI: m/z 695.3 [M+H]+.

Provenance & Evidence