Hydrogen chloride-ethyl acetate → HCID 66812764, compound

Participants

Reaction Steps

A mixture solution of a 4 N hydrochloric acid ethyl acetate solution (97 pt, 0.388 mmol) and methanol (680 pt) was added to a solution of methanol (3 mL) containing N-((Z)-2-(4-cyclopropylphenyl)-1-{[(2-hydroxyethyl)amino]carbonyl}vinyl)-4-{2-[4-(dimethylamino)phenyl]ethoxy}benzamide (133 mg, 0.259 mmol) prepared in Example 25. The resulting mixture was stirred at room temperature for 45 minutes. The reaction mixture was concentrated and dried to give 150 mg of the title compound (white amorphous solid).

Provenance & Evidence