Hydrogen chloride-ethyl acetate → HCID 66812308, compound

Participants

Reaction Steps

A mixture solution of a 4 N hydrochloric acid ethyl acetate solution (27 μL, 0.108 mmol) and methanol (186 pt) was added to a solution of methanol (1 mL) containing 4-{2-[4-(dimethylamino)phenyl]ethoxy}-N-[(Z)-1-{[(2-hydroxyethyl)amino]carbonyl}-2-(4-isopropoxyphenyl)vinyl]benzamide (37.7 mg, 0.071 mmol) prepared in Example 27. The resulting mixture was stirred at room temperature for 40 minutes. The reaction mixture was concentrated and dried to give 42.3 mg of the title compound (white powder, yield: 99%).

Provenance & Evidence