HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenethylic alcohol → N-(4-{2-[3-(Trifluoromethyl)phenyl]ethoxy}benzoyl)glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenethylic alcohol | HCID 95926 | — |
| Reactant | N-(4-Hydroxybenzoyl)glycine tert-butyl ester | HCID 10682169 | — |
| Product | N-(4-{2-[3-(Trifluoromethyl)phenyl]ethoxy}benzoyl)glycine | HCID 66812538 | 80% |
Reaction Steps
The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (502 mg, 2.00 mmol) prepared in Example 1 (1a) and 2-[3-(trifluoromethyl)phenyl]ethanol (330 μL, 2.20 mmol) to give 368 mg of the title compound (white powder, yield: 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497397B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-a77ecea3810e423f8e9743e4b473aca1 |
| Source note | uspto-grants-2013_07 |