N-(4-Hydroxybenzoyl)glycine tert-butyl ester → N-(4-{2-[4-(Trifluoromethyl)phenyl]ethoxy}benzoyl)glycine

Participants

Reaction Steps

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (251 mg, 1.00 mmol) prepared in Example 1 (1a) and 2-[4-(trifluoromethyl)phenyl]ethanol (209 mg, 1.10 mmol) prepared according to the method disclosed in the document (J. Med. Chem., (2002), 45, 4321-4335) to give 278 mg of the title compound (white powder, yield: quantitative).

Provenance & Evidence