1-Hydroxybenzotriazole → HCID 68551805, compound

Participants

Reaction Steps

A mixture of the product from Example 48, Part A (50 mg, 0.08 mmol), N-(3-dimethyl aminopropyl)-N′-ethylcarbodiimide hydrochloride (17 mg, 0.09 mmol), 1-hydroxybenzotriazole (12 mg, 0.09 mmol), Hunig's base (42 uL, 0.24 mmol) and 3-amino-N-cyclopropyl-2-hydroxyhexanamide (WO2002018369-A2; Example 119, cpd xiii′) (15 mg, 0.08 mmol)) in dichloromethane (5 mL) was stirred for 3 hours and diluted with 100 mL EtOAc, washed with 10 mL 1 M H3PO4, 10 mL 10% NaHCO3, 20 mL with brine, dried (MgSO4), and concentrated to give the title compound (31 mg, 49%). MS (ESI+) m/z=790.7 (M+H)+.

Provenance & Evidence