関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-(4-(N-salicyloyl)aminophenyl)propionic acid | HCID 9817303 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | sodium 2-(4-(N-salicyloyl)aminophenyl)propionate | HCID 23700501 | 92.1% |
反応手順
A solution of 53.05 g (0.186 mol) of 2-(4-(N-salicyloyl)aminophenyl-)propionic acid and 300 ml of ethanol is treated with 7.59 g (0.190 mol) of NaOH dissolved in 22 ml of water. The reaction mixture is stirred for 30 min at 25° C. and for 30 min at 0° C. The resulting pale yellow solid is isolated by filtration to give 52.61 g of sodium 2-(4-(N-salicyloyl)aminophenyl)propionate. Properties. Solubility: 200 mg/ml clear solution, pH=6.85. Analysis C, 60.45; H, 5.45; N, 3.92; Na, 6.43. Melting point 236–238° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07186691B2 |
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| 出典データセット | uspto-grants-2007_03 |
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| ORD ID | ord-77f14a7c3825410b87a38dcdac7f5be5 |
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| 出典メモ | uspto-grants-2007_03 |
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