反应详情

A mixture of 3-chloro-N-(2-hydroxyphenyl)propanamide (0.25 g, 1.25 mmol) and aluminium chloride (AlCl3) (0.5 g) was heated with stirring at 130–135° C. for 5 h. After cooling to room temperature, the reaction mixture was quenched with water (3 ml), and extracted with ethyl acetate (3×5 ml). Evaporation of the solvent and flash chromatography of the residue on silica gel with ethyl acetate/heptane (1:1) afforded colourless crystals of the subtitled compound (95 mg, 46.5%).

1. temperaturewas heated
2. customthe reaction mixture was quenched with water (3 ml)
3. extractionextracted with ethyl acetate (3×5 ml)
4. customEvaporation of the solvent and flash chromatography of the residue on silica gel with ethyl acetate/heptane (1:1)