Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Product | HCID 1510394 | HCID 1510394 | 66.4% |
Reaction Steps
To a stirred mixture of 2-aminophenol (3.0 g, 27.5 mmol), potassium carbonate (6.0 g, 43.4 mmol) and DMF (25 mL) 1-(bromomethyl)benzene (3.75 mL, 31.3 mmol) was added. The mixture was stirred at 60° C. overnight. Purification by preparative HPLC (Kromasil C18; eluant:acetonitrile+0.1% TFA/water+0.1% TFA) gave the subtitled compound (1.82 g, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07186718B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-0a2badedcef64ffb8efd60beb66f977b |
|---|
| Source note | uspto-grants-2007_03 |
|---|
